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Pre-transplant Evaluation
Because a stem cell transplant
involves the administration of high doses of chemotherapy and/or
total body irradiation, we have
to be certain that your body is strong enough to handle this
treatment. You must undergo extensive testing of your heart, lungs,
kidneys, liver, and blood. Below you will find a comprehensive list
of tests which will be done as part of your pre-transplant
evaluation.
1. Lab evaluation:
a) Hematology:
CBC with differential
PT/INR/PTT
ABO group and Rh type and antibody screen
b) Chemistry:
Sodium, Potassium, Chloride, Bicarbonate
Glucose
Calcium, Albumin
Magnesium
Phosphate
BUN, Creatinine
Total Bilirubin (direct and indirect if total bilirubin is
elevated)
Alkaline Phosphatase
AST, ALT
Total Protein
LDH, Uric Acid
c) Serology: (must be documented within 30 days prior to first day
of stem cell collection)
Cytomegalovirus serology (*Anti-CMV IgG)
Herpes simplex virus serology (HSV I & II)
Varicella zoster virus (VZV) serology
HIV serology (*Anti-HIV-1, *Anti-HIV-2)
*HIV-1 Antigen
*Anti-HTLV 1 and 2
Serologic test for syphylis:
*RPR
Hepatitis A:
Anti-HAV IgM and IgG
Hepatitis B:
*HbsAg - surface antigen
*Anti-HBc
Anti-HBs - surface antibody
Hepatitis C:
*Anti-HCV
(* FACT specified)
d) Pregnancy test (performed on all women of child-bearing
potential)
e) HLA-typing (A, B, DR)
f) Staging studies (as appropriate for specific disease):
Bone scan
CT scans: head, neck, chest, abdomen, pelvis
Bone marrow studies:
Morphology
Immunophenotype
Cytogenetics
DNA Studies (PCR)
FISH
Gallium Scan
MRI
Tumor markers
Skeletal survey
SPEP, SPIEP, Ig’s, Beta-2 microglobulin
g) Pulmonary assessment:
CXR- PA, Lat
PFT's
h) Cardiac assessment:
EKG
MUGA or ECHO
i) Dental evaluation:
Panorex
Assessment by dentist
j) Renal evaluation:
Urine analysis
24 hour urine for creatinine clearance
2. Physical examination.
3. Tissue typing (done on blood).
4. Psychosocial evaluation.
Click here to continue to the next step
(donor evaluation).
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