Pre-transplant Evaluation

Because a stem cell transplant involves the administration of high doses of chemotherapy, we have to be certain that your body is strong enough to handle this treatment. You must undergo extensive testing of your heart, lungs, kidneys, liver, and blood. Below you will find a comprehensive list of tests which will be done as part of your pre-transplant evaluation.

1. Lab evaluation:

a) Hematology:

CBC with differential

PT/INR/PTT

ABO group and Rh type and antibody screen

b) Chemistry:

Sodium, Potassium, Chloride, Bicarbonate

Glucose

Calcium, Albumin

Magnesium

Phosphate

BUN, Creatinine

Total Bilirubin (direct and indirect if total bilirubin is elevated)

Alkaline Phosphatase

AST, ALT

Total Protein

LDH, Uric Acid

c) Serology: (must be documented within 30 days prior to first day of stem cell collection)

Cytomegalovirus serology (*Anti-CMV IgG)

Herpes simplex virus serology (HSV I & II)

Varicella zoster virus (VZV) serology

HIV serology (*Anti-HIV-1, *Anti-HIV-2)

*HIV-1 Antigen

*Anti-HTLV 1 and 2

Serologic test for syphylis:

*RPR

Hepatitis A:

Anti-HAV IgM and IgG

Hepatitis B:

*HbsAg - surface antigen

*Anti-HBc

Anti-HBs - surface antibody

Hepatitis C:

*Anti-HCV

(* FACT specified)

d) Pregnancy test (performed on all women of child-bearing potential)

e) HLA-typing (A, B, DR)

f) Staging studies (as appropriate for specific disease):

Bone scan

CT scans: head, neck, chest, abdomen, pelvis

Bone marrow studies:

Morphology

Immunophenotype

Cytogenetics

DNA Studies (PCR)

FISH

Gallium Scan

MRI

Tumor markers

Skeletal survey

SPEP, SPIEP, Ig’s, Beta-2 microglobulin

g) Pulmonary assessment:

CXR- PA, Lat

PFT's

h) Cardiac assessment:

EKG

MUGA or ECHO

i) Dental evaluation:

Panorex

Assessment by dentist

j) Renal evaluation:

Urine analysis

24 hour urine for creatinine clearance

 

2. Physical examination

3. Psychosocial evaluation.

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